一 | Harvard-affiliated scientists say they have been able to keep a monkey alive for two years with a genetically engineered pig kidney. Although preliminary, transplant experts say this research is an important milestone in the search for an alternative source of organs.Scientists are hopeful that one day, genetically modified organs grown in pigs may be able to significantly extend the life of people with end-stage organ failure.In recent months, other high-profile research teams at New York University and the University of Alabama at Birmingham announced successful transplants of genetically modified pig-kidneys into brain dead human donors. But those experiments ended after a few weeks."Duration of survival has been an Achilles heel of genetically modified pig organs to date due to a combination of rejection and opportunistic infections," said Dr. Peter Chin-Hong, director of the transplant infectious disease program at University of California, San Francisco.This new research, published in Nature, represents the longest period of time that scientists have been able to keep a non-human primate research animal alive."This proof-of-concept study provides real hope that transplantation of porcine [pig] donor kidneys into humans is very much on the horizon," Chin-Hong said.Still, experts cautioned that this new research was preliminary, and the idea of pig-grown organs is likely several years away from becoming a reality."If ultimately proved successful in human organ recipients - which is still years away at this point - this could be one of the key advances needed to make xenotransplantation a reality in clinical practice," said Dr. Josh Levitsky, president of the American Society of Transplantation.The new research was led by eGenesis, a company co-founded by Harvard geneticist George Church. In a press release, scientists at eGenesis said the new research will help lay the groundwork for formal clinical trials.In prepared remarks, eGenesis CEO Michael Curtis, PhD, said the company is focused on "improving long-term survival for transplant recipients from months to years."Eventually, the hope is that transplant doctors will be able to use genetically modified pig organs instead of solely relying on deceased human organ donors."Among all solid organs transplanted, kidneys are most sought after, expected to increase in demand further, and there is a significant shortfall of organs leading to premature deaths," Chin-Hong said.Every day, 17 people die waiting on the organ transplant list, according to the Health Resources & Services Administration. There are currently more than 100,000 people waiting on the national transplant list and a new person is added to the list every 10 minutes.。
二 | 南洋理工大学（NTU）近日发布了一项引人注目的研究，揭示了登革热患者在康复一年后面临的长期健康风险。根据这项由NTU李光前医学院（LKCMedicine）领导的全国性研究，与新冠肺炎康复者相比，登革热患者在康复后一年内出现心脏并发症的风险高出55%。来源：OnlyMyHealth官网研究研究分析了2021年7月至2022年10月期间新加坡11,707名登革热患者和1,248,326名新冠肺炎患者的医疗记录。研究对象包括感染Delta和Omicron变种病毒的新冠患者，研究团队通过比较康复31至300天内出现的新发健康问题，尤其关注心脏、神经系统和免疫系统的并发症。研究显示，登革热康复者更容易出现如心律不齐、心脏病和血栓等心脏问题。相比之下，新冠康复者虽然也存在健康风险，但登革热患者面临的长期并发症风险更高。这项研究是全球首个对比登革热与新冠肺炎患者长期健康风险的研究。来源：NTU官网研究发表在2024年7月的《Journal of Travel Medicine》上，旨在帮助公共卫生部门更好地理解登革热的长期影响，并为预防和管理该疾病提供科学依据。NTU李光前医学院的传染病建模助理教授Lim Jue Tao领导了这项研究。他表示，气候变化导致登革热的地理传播范围扩大，进一步加剧了这一问题。教授指出，登革热是全球最常见的蚊媒传染病之一，康复后出现的长期健康问题可能显著增加个人和社会的医疗负担。研究团队呼吁公众加强对登革热的防范措施，特别是在环境中做好防蚊工作，以降低感染和并发症的风险。研究还为公共卫生规划提供了重要的资源，帮助制定更有效的防控策略，以应对登革热对健康的长期影响。来源：NTU官网通过这项研究，NTU再次展示了其在推动全球健康问题研究方面的领导地位。未来，NTU将继续致力于研究与应对登革热和其他传染病的长期健康影响。
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